Clinical Trial: Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

Brief Summary:

Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm.

The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.

Detailed Summary:
Sponsor: Nikolaj Eldrup

Current Primary Outcome: Reduction in myocardial infarction [ Time Frame: 4 to 5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Improvement in survival Description on inflammatory response [ Time Frame: 4 to 5 years ]

Original Secondary Outcome: Same as current

Information By: Aarhus University Hospital

Dates:
Date Received: April 15, 2009
Date Started: April 2009
Date Completion:
Last Updated: January 12, 2015
Last Verified: January 2015