Clinical Trial: Safety and Effectiveness of tPA in Intra-abdominal Abscesses
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Safety and Effectiveness of Local Instillation of tPA in the Management of Complex Intra-abdominal Fluid Collections: a Randomized, Double Blinded Controlled Clinical Trial
Brief Summary: To determine if instillation of tissue plasminogen activator into a percutaneously drained intra-abdominal abscess cavity results in faster resolution of the abscess compared to normal standard of care.
Detailed Summary: On day 0 Subjects will have Tissue Plasminogen Activator injected into a drainage tube and allowed to dwell in the intra-abdominal abscess for one hour before allowing it to drain by gravity. This will be repeated on day 1 and 2.
Sponsor: University Health Network, Toronto
Current Primary Outcome:
- time to eating [ Time Frame: tbd ]
- time to discharge [ Time Frame: tbd ]
- radiological evidence of resolution [ Time Frame: tbd ]
Original Primary Outcome:
- time to eating
- time to discharge
- radiological evidence of resolution
Current Secondary Outcome: cost comparison [ Time Frame: tbd ]
Original Secondary Outcome: cost comparison
Information By: University Health Network, Toronto
Dates:
Date Received: January 2, 2007
Date Started: July 2005
Date Completion:
Last Updated: January 13, 2014
Last Verified: January 2014
