Clinical Trial: Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery

Brief Summary: The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important. In case of alteration of the glycocalyx, experimental models and some clinical studies show an increased capillary leak responsible for interstitial edema. The analysis of glycocalyx in routine care is important to guide volume expansion. Indeed, the literature provides evidence about the poor prognosis of excess water and its impact on organ. This analysis challenge is to justify filling solution of choice according to the characteristic of this capillary leakage.

Detailed Summary:

Extra corporeal circulation and aortic clamp induce ischemia-reperfusion damages.

Vascular damages are represented by first glycocalyx, a layer of endovascular vessel proteoglycans, responsible for fluid permeability and secondly by nitro oxygen liberation responsible for vascular tonus.

The investigators suppose that both functions are impaired after cardiac surgery.


Sponsor: Centre Hospitalier Universitaire, Amiens

Current Primary Outcome: glycocalyx proteins 1 [ Time Frame: 48 hours ]

proteoglycan in patient plasma is assayed.


Original Primary Outcome:

  • glycocalyx proteins 1 [ Time Frame: 48 hours ]
    proteoglycan in patient plasma is assayed.
  • glycocalyx proteins 2 [ Time Frame: 48 hours ]
    heparan-sulfate in patient plasma is assayed
  • glycocalyx proteins 3 [ Time Frame: 48 hours ]
    syndecan-1 in patient plasma is assayed


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Centre Hospitalier Universitaire, Amiens

Dates:
Date Received: July 7, 2016
Date Started: August 2016
Date Completion: February 2017
Last Updated: January 30, 2017
Last Verified: January 2017