Clinical Trial: Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots

Brief Summary: This research study is studying identification of de novo Fanconi anemia in younger patients with newly diagnosed acute myeloid leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to Fanconi anemia in patients with acute myeloid leukemia.

Detailed Summary:

PRIMARY OBJECTIVES:

I. Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961 and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia.

II. Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi anemia patients using western blot techniques.

OUTLINE:

Previously collected cryopreserved cells are analyzed via western blot to identify patients with Fanconi anemia.


Sponsor: Children's Oncology Group

Current Primary Outcome:

  • Identification of children at high risk of having Fanconi anemia [ Time Frame: Up to 5 months ]
  • Identification of Fanconi anemia patients [ Time Frame: Up to 5 months ]


Original Primary Outcome:

  • Identification of children at high risk of having Fanconi anemia
  • Identification of Fanconi anemia patients


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Children's Oncology Group

Dates:
Date Received: June 16, 2010
Date Started: May 2009
Date Completion:
Last Updated: May 13, 2016
Last Verified: May 2016