Clinical Trial: Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

Brief Summary:

Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients.

Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied.

The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.

Detailed Summary:

Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center.

Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.

Sponsor: HaEmek Medical Center, Israel

Current Primary Outcome: Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia [ Time Frame: One year ]

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: HaEmek Medical Center, Israel

Dates:
Date Received: September 3, 2009
Date Started: January 2009
Date Completion:
Last Updated: August 30, 2015
Last Verified: August 2015