Clinical Trial: Energy Metabolism in Patients With Short Bowel Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Assessment of Energy Metabolism in Patients With Short Bowel Syndrome Using the Doubly Labeled Water Method

Brief Summary: This study proposes to verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method, as well as determining the rate of oxidation of nutrients, aiming to assist the management of nutritional therapy for these patients.

Detailed Summary:
Sponsor: University of Sao Paulo

Current Primary Outcome: Assessment of total energy expenditure using the doubly labeled water method [ Time Frame: 14 days ]

After the determination of resting energy expenditure (REE), each volunteer will receive a dose of doubly labeled water (2H2 18O). A basal urine sample is collected before the intake dose and samples taken on days 1, 2, 3, 7, 12, 13, 14, thereafter. Urine samples will be analyzed by mass spectrometry (Hydra System, HIP 20-20, Europa Scientific, Cheshire, UK) in the Mass Spectrometry Laboratory of the Faculty of Medicine of Ribeirão Preto.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Resting energy expenditure (REE) and body composition measurements by indirect calorimetry and electrical bioimpedance, respectively. [ Time Frame: After 12 hours of overnight fasting ]
    This study also aims to measure the REE by indirect calorimetry with a Quark (Cosmed, Italy) calorimeter and the body composition by Byodinamics 450 (Biodynamics Corp., United States).
  • Physical activity assessment [ Time Frame: 14 days ]
    An activity monitor (activPAL ®, Glasgow, UK) is used to determine physical activity. By registering the intensity and duration of each category of activities, the system adds the energy estimated to generate a value that reflects the total energy expenditure.


Original Secondary Outcome: Same as current

Information By: University of Sao Paulo

Dates:
Date Received: April 10, 2014
Date Started: March 2013
Date Completion:
Last Updated: December 2, 2014
Last Verified: December 2014