Clinical Trial: Acetyl-L-Carnitine in the Treatment of Septic Shock

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Prospective, Randomized, Placebo-controlled, Double-Blinded, Phase II Pilot Study of Acetyl-L-carnitine in the Treatment of Patients With Septic Shock

Brief Summary: This placebo-controlled study investigates acetyl-L-carnitine in the treatment of septic shock requiring vasopressors.

Detailed Summary: This is a cross-over study which infuses ALC for 12 out of 18 hours (and placebo the other 6). Patients must have vasopressor-dependent septic shock and be free from renal failure, hepatic failure, and seizures to be eligible.
Sponsor: Vanderbilt University

Current Primary Outcome:

  • Mean Arterial Blood Pressure [ Time Frame: 18 hours ]
    Mean Arterial blood pressure measured non-invasively at 18 hours
  • Vasopressor Dose [ Time Frame: 6-24 hours ]


Original Primary Outcome:

  • Mean Arterial Blood Pressure [ Time Frame: 24-36 hours ]
  • Vasopressor Dose [ Time Frame: 6-24 hours ]


Current Secondary Outcome: Serum Lactate [ Time Frame: 12-36 hours ]

Original Secondary Outcome: Same as current

Information By: Vanderbilt University

Dates:
Date Received: January 2, 2008
Date Started: August 2006
Date Completion:
Last Updated: January 16, 2014
Last Verified: January 2014