Clinical Trial: Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients

Brief Summary: After initial hemodynamic stabilization, 36 septic shock patients with heart rate > of 90 bpm and requiring norepinephrine to maintain mean arterial pressure (MAP) more than 65 mmHg will be randomised into two groups, esmolol group and control group. Patients allocated to esmolol group will receive a continuous esmolol infusion to maintain a lowering of heart rate of 10%. Norepinephrine will be titrated to achieve a MAP more than 65 mmHg. To investigate myocardial performance, the investigators will assess Tissue Doppler imaging by echocardiography and hemodynamic measures. Data will be obtained at baseline ,after esmolol infusion once achieved the predefined heart rate threshold and 72hours after esmolol infusion.

Detailed Summary: primary outcome were determined according to our previous study of tissue doppler.
Sponsor: Peking Union Medical College Hospital

Current Primary Outcome: Echocardiographic assessment of heart function [ Time Frame: over a period of 72 hrs ]

peak systolic velocity measured at the mitral annulus decreased 30% compared with control group


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Effects on vasopressor requirement [ Time Frame: over a period of 72 hrs ]
    Dosage of norepinephrine increased 100% compared with control group
  • 90-day hospital mortality [ Time Frame: 90 days ]


Original Secondary Outcome: Same as current

Information By: Peking Union Medical College Hospital

Dates:
Date Received: July 14, 2016
Date Started: December 2014
Date Completion: December 2016
Last Updated: July 22, 2016
Last Verified: July 2016