Clinical Trial: Comparison of Vasopressin and Other Pressors in Septic Shock
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Comparative Prospective Study of Vasopressin and Catecholamine in Septic Shock
Brief Summary:
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
Vasopressin seems to be an interesting alternative in the treatment of septic shock. To this date, available studies have showed that it could correct hyperkinetic syndrome and vasoplegia in septic shocks without noticeable side effect. It as been demonstrated that vasopressin improves renal function, as no effect on digestive organs and as no metabolic effect.
Detailed Summary:
Sponsor: Université de Sherbrooke
Current Primary Outcome: To compare the efficiency of vasopressine to the standard and usual treatment of septic shock on the reverse of the hemodynamic criterion of septic shock
Original Primary Outcome: Same as current
Current Secondary Outcome:
- To compare these two categories of treatment on:
- tonometric parameters
- renal function
- in term of tolerance: metabolic effects (increase in lactate and glycaemia), cardiac effects (tachycardia being defined as a heart rate increase of 15%), increase of cardiac enzymes (troponine, CK, CK-MB), and cutanuous vasoconstriction.
Original Secondary Outcome: Same as current
Information By: Université de Sherbrooke
Dates:
Date Received: December 22, 2005
Date Started: July 2000
Date Completion:
Last Updated: May 26, 2006
Last Verified: August 2005
