Clinical Trial: Tryptophan, Serotonin and Kynurenine in Septic Shock

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Tryptophan, Serotonin and Kynurenine in Septic Shock

Brief Summary: Septic shock is a major cause of mortality and morbidity worldwide. Serotonin (5-HT) is released by activated platelets into the circulation, and is mediator of endothelial dysfunction. 5-HT metabolism is known in immune system via specific 5-HT receptor, also in effects on the peripheral nervous system. Kinetic of 5-HT, tryptophan, kynurenine, MAO activity and IDO activity in human septic shock was never investigated.

Detailed Summary:
Sponsor: Versailles Hospital

Current Primary Outcome: Kinetics of 5-HT, 5-HIAA, kynurenine, tryptophan, HVA, VMA, DOPAC, Oestradiol, Cotinine and vasopressors [ Time Frame: Day-1, Day-2, Day-3, Day-7 and Day-14 ]

Original Primary Outcome: Mortality [ Time Frame: 28-day ]

Current Secondary Outcome: Mortality [ Time Frame: 28-day ]

Original Secondary Outcome: Kinetics of 5-HT, 5-HIAA, kynurenine, tryptophan, HVA, VMA, DOPAC, Oestradiol, Cotinine and vasopressors [ Time Frame: Day-1, Day-2, Day-3, Day-7 and Day-14 ]

Information By: Versailles Hospital

Dates:
Date Received: May 22, 2008
Date Started: June 2004
Date Completion:
Last Updated: August 7, 2008
Last Verified: May 2008