Clinical Trial: Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood
Brief Summary:
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer.
PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.
Detailed Summary:
OBJECTIVES:
- To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.
Sponsor: Children's Oncology Group
Current Primary Outcome: Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Children's Oncology Group
Dates:
Date Received: April 5, 2012
Date Started: April 2012
Date Completion:
Last Updated: July 13, 2016
Last Verified: July 2016
