Clinical Trial: Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title:

Brief Summary: Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea, lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation. Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage. We therefore undertook an analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal chest radiograph in order to improve understanding of disease pathogenesis and improve patient management.

Detailed Summary:
Sponsor: National Taiwan University Hospital

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Information By: National Taiwan University Hospital

Dates:
Date Received: September 12, 2005
Date Started:
Date Completion:
Last Updated: September 12, 2005
Last Verified: July 2004