Clinical Trial: Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

Brief Summary: The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.

Detailed Summary: Encephalopathy is a common complication of sepsis, impaired cerebrovascular autoregulation (AR) in patients with sepsis is considered related to Sepsis-associated encephalopathy (SAE). As AR is important in stabilizing the cerebral perfusion pressure, whether greater variability of CPP is related to SAE and mortality or not remains unclear. We conduct this study to evaluate the relationship between them.
Sponsor: Kang Yan

Current Primary Outcome: relationship between cerebral perfusion pressure variability and sepsis-associated encephalopathy [ Time Frame: cerebral perfusion pressure is assessed up to 72 hours ]

To estimate CPP noninvasively, we will monitor the middle cerebral artery flow velocity of patients with sepsis using transcranial Doppler ultrasound in the first 72h of their enrollment. Diagnosis of a SAE was performed using the confusion assessment method for ICU(CAM-ICU).


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Duration of mechanical ventilation [ Time Frame: All the participants will be followed up until discharge or death, assessed up to 12 months ]
  • Time of ICU stay [ Time Frame: All the participants will be followed up until discharge or death, assessed up to 12 months ]
  • Time of hospital stay [ Time Frame: All the participants will be followed up until discharge or death, assessed up to 12 months ]
  • 90-day mortality rate [ Time Frame: All the participants will be followed up until 90 days after their enrollment or death ]
  • 1-year mortality rate [ Time Frame: All the participants will be followed up until 1 year after their enrollment or death ]
  • Quality of life of survivors [ Time Frame: All the participants will be followed up until 1 year after their enrollment or death ]
    Instrumental Activity of Daily living (IADL) and Glasgow Outcome Scale (GOS) will be used to evaluate quality of life of survivors


Original Secondary Outcome: Same as current

Information By: West China Hospital

Dates:
Date Received: October 27, 2014
Date Started: March 2014
Date Completion: September 2016
Last Updated: November 6, 2014
Last Verified: November 2014