Clinical Trial: Angiogenic/Angiostatic Mediators in Patients With Systemic Sclerosis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Endostatin and Other Angiogenic/Angiostatic Mediators in Patients With Systemic Sclerosis

Brief Summary: We propose to examine several angiogenic/angiostatic mediators in the skin and serum of subjects with SSc and compare it to levels found in the skin and serum of healthy subjects.

Detailed Summary: Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis of the skin and internal organs. One of the earliest pathologic changes in patients with SSc is damage to the blood vessels. Many abnormalities have been found in the inner layer of the blood vessel, the enothelial tissue. It is known that there are mediators in the blood and tissues of the body that affect the endothelial tissue. These are called angiogenic (promote blood vessel formation) and angiostatic (inhibit blood vessel formation) mediators. Many of these mediators have been examined in the peripheral blood of patients with SSc, but fewer of these mediators have been examined at the site of action, in the tissue near the microvasculature. We hypothesize that there are differences in the levels of angiogenic/angiostatic mediators between healthy subjects and subjects with SSc. In addition, we propose that there are differences at skin sites that have varying levels of involvement with SSc of these angiogenic/angiostatic factors in subjects with SSc.
Sponsor: University of Michigan

Current Primary Outcome: Level of endostatin in skin and serum [ Time Frame: At time of of biopsy and blood draw ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Level of JAM-A in skin and serum [ Time Frame: At time of blood draw and skin biopsy ]

Original Secondary Outcome: Same as current

Information By: University of Michigan

Dates:
Date Received: April 25, 2008
Date Started: May 2007
Date Completion:
Last Updated: October 24, 2016
Last Verified: October 2016