Clinical Trial: Causes of Visual Loss in Retinal Disease

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Observational Study of Visual Outcomes in Retinal Disease

Brief Summary: This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.

Detailed Summary: This is a study of visual outcomes in retinal disease. It is an observational study of patients who have been seen in the retinal clinic, and involves a retrospective casenotes analysis to identify patients who have suffered visual loss and the reason for that visual loss. These data will be analysed to enable the identification of factors that predict visual loss in patients who present earlier in the course of their disease.
Sponsor: Royal Surrey County Hospital

Current Primary Outcome: Visual acuity at 5 years [ Time Frame: 5 years ]

Best-corrected visual acuity at 5 years


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Visual acuity at 10 years [ Time Frame: 10 years ]
    Best corrected visual acuity at 10 years
  • Source of referral [ Time Frame: Baseline ]
    Categorised as A&E/GP referral/Optician referral/Tertiary referral
  • Laterality [ Time Frame: Baseline ]

    Categorised as:

    Right eye/Left eye/Bilateral

  • Anatomical diagnosis [ Time Frame: Baseline ]

    Cateogorised as:

    Acute anterior uveitis / Chronic anterior uveitis / Fuchs heterochromic cyclitis / Intermediate uveitis / Pars planitis / Posterior Uveitis / Panuveitis / Episcleritis / Scleritis

  • Aetiological diagnosis [ Time Frame: Baseline ]

    Diagnosed as:

    Viral / Bacterial / Fungal / Parasitic / Inflammatory / Malignant

  • Associated systemic disease [ Time Frame: Baseline ]
    Any associated systemic disease, e.g. HLA-B27 associated disease, Behcet's disease, multiple sclerosis, Vogt-Koyanagi-Harada syndrome, rheumatoid arthritis, collagen vascular disease, tuberculosis, granulomatosis with polyangiitis
  • Complications of disease and causes of visual loss at 5 years [ Time Frame: 5 years ]

    Categorised into:

    Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other

  • Complications of disease and causes of visual loss at 10 years [ Time Frame: 10 years ]

    Categorised into:

    Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other

  • Complications of disease and causes of visual loss [ Time Frame: Up to 10 years ]

    Categorised into:

    Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other

  • Treatment measures employed [ Time Frame: Up to 10 years ]

    Categorised into:

    Topical treatment / periocular steroid / intraocular steroid / intraocular other agent / Glaucoma treatment / systemic immunosuppressive agents

  • Complications of disease and treatment [ Time Frame: Up to 10 years ]

    Categorised into:

    1. Local complications: Raised intraocular pressure / cataract / endophthalmitis / other
    2. Systemic complications: Diabetes / hypertension / cholesterol / liver function / bone density loss / other
  • Surgical procedures [ Time Frame: Up to 10 years ]
    List and dates of any intraocular surgery performed during the study
  • Burden of disease - appointments [ Time Frame: Up to 10 years ]
    Number of outpatient appointments over the course of the study
  • Burden of disease - outpatient procedures [ Time Frame: Up to 10 years ]
    Number of outpatient procedures over the course of the study
  • Burden of disease - inpatient procedures [ Time Frame: Up to 10 years ]
    Number of inpatient procedures over the course of the study
  • Blind registration [ Time Frame: Up to 10 years ]
    Year of any registration as partially sighted or blind


Original Secondary Outcome: Same as current

Information By: Royal Surrey County Hospital

Dates:
Date Received: May 29, 2012
Date Started: May 2012
Date Completion: December 2012
Last Updated: June 5, 2012
Last Verified: June 2012