Clinical Trial: Perichondrium Autograft in Refractory Necrotizing Scleritis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Autologous Perichondrium Transplantation for Replacement of Stem Cells and Their Niche in the Treatment of Necrotizing Scleritis

Brief Summary:

Necrotizing scleritis with severe ischemia is refractory to conventional treatment because of avascular necrosis.

The investigators assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in patients with severe ischemic necrotizing scleritis, and analyzed the therapeutic effects.

Detailed Summary:

Ischemic necrotizing scleritis patients who showed persistent and progressive scleral melting were included in this study.

Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect after the necrotic tissue removal.

Sponsor: Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Current Primary Outcome: Success Rate of Repair of Scleral Defects [ Time Frame: Six months after reconstructive surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Post-Operative Complications [ Time Frame: Six months after reconstructive surgery ]

Original Secondary Outcome: Same as current

Information By: Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Dates:
Date Received: July 21, 2016
Date Started: March 2011
Date Completion:
Last Updated: August 9, 2016
Last Verified: August 2016