Clinical Trial: Cause and Importance of the Age-dependent Sarcopenia
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Cause and Importance of the Age-dependent Sarcopenia With a Blood Based Bioenergetics & Cytokine Profiling Approach
Brief Summary: The goal of this cross-sectional study is to evaluate the difference in cytokine profiling approach and mitochondrial function between geriatric sarcopenic patients (group 1) and geriatric non-sarcopenic patients (group 2) and healthy (group 3) geriatric participants.
Detailed Summary:
Study participants (group 1&2) are assessed during the hospital stay and age-matched controls (group 3) will be recruited through Flyers.
The investigators aim to isolate and cryopreserve peripheral blood mononuclear cells (PBMCs) from whole blood to perform functional assays on mitochondrial respiratory capacity and ROS. Furthermore, the investigators will investigate the association between biomarkers and frailty, quality of life, functional performance, fatigue and risk of depression.
The investigators hypothesize that this profiling approach will allow the evaluation of the progression of age-dependent sarcopenia and uncover novel therapeutic targets.
Sponsor: Charite University, Berlin, Germany
Current Primary Outcome: Differences in mitochondrial respiratory capacity of peripheral blood mononuclear cells (PBMCs) using Oxygraph-2k respirometry [ Time Frame: Baseline ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Quality of life (validated questionnaire) [ Time Frame: Baseline ]
- Frailty Status according to Fried et.al. criteria [ Time Frame: Baseline ]
- Functional limitations (single validated questionnaire) [ Time Frame: Baseline ]
Original Secondary Outcome: Same as current
Information By: Charite University, Berlin, Germany
Dates:
Date Received: December 7, 2016
Date Started: November 2016
Date Completion: November 2019
Last Updated: December 13, 2016
Last Verified: December 2016
