Clinical Trial: Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis

Brief Summary: The goal of the current study is to evaluate the potential of the selected PET tracers to detect sarcoidotic lesions in lungs. The tracers are already in clinical use for the detection of certain inflammatory processes or malignant tumors, and their targets present similarities with molecular mechanisms of sarcoidosis.

Detailed Summary:

The diagnosis of sarcoidosis is difficult since there is no specific noninvasive method available to diagnose sarcoidosis. FDG-PET imaging is in use, however, FDG is not a specific tracer for sarcoidosis and other inflammatory diseases may interfere with the imaging findings. The aim of the current protocol is to evaluate the potential of other inflammatory PET-tracers in the detection of sarcoidotic lesions.

The patients with active sarcoidotic lesions in lungs will be recruited. First, the patient undergoes PET-FDG scan and then the patient undergoes the PET scan either with C11-methionine or 68Ga-DOTANOC. The results with the latter tracers will be compared to the imaging results with FDG.


Sponsor: Turku University Hospital

Current Primary Outcome: The detection of sarcoidotic lesion with C11-methionine or 68Ga-DOTANOC. [ Time Frame: baseline ]

Qualitative assessment of tracer uptake in sarcoidotic lesions.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Turku University Hospital

Dates:
Date Received: May 27, 2016
Date Started: May 2016
Date Completion: December 2017
Last Updated: July 1, 2016
Last Verified: July 2016