Clinical Trial: Salivary Markers in Patients With Xerostomia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: Oral Health and Salivary Markers in Patients With Xerostomia

Brief Summary: The purpose of this study was to investigate the salivary levels of inflammatory and their association with oral health in xerostomía patient

Detailed Summary:

Primary Outcome Measures:

• salivary Proinflammatory and anti-inflammatory cytokines
• questionnaire is provided to the patient for xerostomia characterization

Secondary Outcome Measures:

• Probing pocket depth
• Probing pocket depth and clinical attachment level
• Gingival index
• Plaque index
• Bleeding on probing

Current Primary Outcome:

• saliva flow rate [ Time Frame: 2 months ]
  Unstimulated salivary flow rate. Pathological < or 1.5 ml/ 15 minutes.
• Xerostomia [ Time Frame: 2 months ]
  Visual Analogue Scale (VAS) for xerostomia severity (0 cm: no xerostomía , 10cm : very severe xerostomia ).
• Interleukins [ Time Frame: 2 months ]
  Analytes in saliva IFN-(pg/ml), IL-10(pg/ml), IL-1b(pg/ml), IL-4 (pg/ml)and IL-6 (pg/ml)

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Oral Exam [ Time Frame: 4 months ]
  Caries number, natural teeth number
• Periodontal evaluation [ Time Frame: 4 months ]
  periodontal( gingival index, bleeding index, clinical attachment level, probing depth,number dental implant .A periodontal probe will be inserted between the tooth and the gum in the gingival sulcus and a measurement of the pocket depth will be measured by a trained dentist in all subjects according to American Academy of Periodontology classification of periodontal diagnosis

Original Secondary Outcome: Same as current

Information By: Universidad de Murcia

Dates:
Date Received: May 1, 2017
Date Started: January 2016
Date Completion: July 2017
Last Updated: May 15, 2017
Last Verified: May 2017