Clinical Trial: BK Virus in Salivary Gland Disease: Treating the Potential Etiologic Agent
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: BK Virus in Salivary Gland Disease
Brief Summary: The purpose of this study is to analyze BK viral infection in salivary gland diseases; specifically, to determine a definitive relationship between BK Virus and HIV associated salivary gland disease (HIVSGD). Participants are adults HIV+SGD+ who will be randomized 1:1 to receive BK Virus antiviral (ciprofloxacin) or placebo for 28 days. Salivary function/protein secretion will be correlated with BK polyomavirus titers. We expect that patients with HIV+SGD+ will have elevated oral BK polyomavirus viral loads and will benefit from Ciprofloxacin.
Detailed Summary:
Sponsor: University of North Carolina, Chapel Hill
Current Primary Outcome: (BK) Virus replication and shedding [ Time Frame: 12 weeks ]
Original Primary Outcome: BKV replication and shedding [ Time Frame: 12 weeks ]
Current Secondary Outcome: Salivary function [ Time Frame: 12 weeks ]
Original Secondary Outcome: Salivary function [ Time Frame: 12 weeks ]
Information By: University of North Carolina, Chapel Hill
Dates:
Date Received: February 19, 2014
Date Started: April 2014
Date Completion: April 2018
Last Updated: April 17, 2017
Last Verified: April 2017