Clinical Trial: Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

Brief Summary:

New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.

In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.

Detailed Summary:
Sponsor: Chosun University Hospital

Current Primary Outcome: The primary end point was the fever clearance time [ Time Frame: 4 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: The secondary end point was evaluated according to the following definitions. "Cure ", "Failure", "Relapse" [ Time Frame: 4 years ]

Original Secondary Outcome: Same as current

Information By: Chosun University Hospital

Dates:
Date Received: December 5, 2007
Date Started: September 2006
Date Completion: December 2009
Last Updated: December 5, 2007
Last Verified: December 2007