Clinical Trial: Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Effects of Growth Hormone Treatment on Body Proportions and Final Height Among Small Children With X-Linked Hypophosphatemic Rickets

Brief Summary: X-linked hypophosphatemic rickets (XLH) is characterized by rickets, disproportionate short stature, impaired renal phosphate reabsorption and vitamin D metabolism. Despite oral phosphate and vitamin D treatment, most children with XLH demonstrate reduced adult height. The main objective of the study is to determine the beneficial effects of recombinant human growth hormone (rhGH) therapy on body proportions after 36 month in these patients. Secondary objective is to monitor side effects of the therapy.

Detailed Summary:
Sponsor: University of Rostock

Current Primary Outcome: change of body proportion and final height [ Time Frame: within 5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: side effects of therapy with rhGH [ Time Frame: within 5 years ]

Original Secondary Outcome: Same as current

Information By: University of Rostock

Dates:
Date Received: May 11, 2007
Date Started: August 2004
Date Completion: August 2009
Last Updated: May 11, 2007
Last Verified: May 2007