Clinical Trial: Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation
Brief Summary: This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge. Ten vasomotor rhinitis (VMR) patients with nasal symptoms triggered predominantly by cold air, four VMR patients with symptoms triggered predominantly by chemicals, and ten nonallergic, non-rhinitic control subjects will be studied.
Detailed Summary: After initial screening and verification that subjects can cooperate with active posterior rhinomanometry, subjects will be scheduled for two 15-minute exposure sessions with either: cold-dry air, or warm-moist air. Subjects will rate symptoms (and have their nasal airway resistance measured in triplicate) prior to exposure and at 15-min. intervals post-exposure until an hour has passed.
Sponsor: Associated Scientists to Help Minimize Allergies
Current Primary Outcome: Net Proportional Change in Nasal Airway Resistance [ Time Frame: One hour ]
Original Primary Outcome: symptom rating + nasal airway resistance
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Associated Scientists to Help Minimize Allergies
Dates:
Date Received: December 21, 2006
Date Started: December 2006
Date Completion:
Last Updated: January 23, 2017
Last Verified: January 2017