Clinical Trial: Sensitivity and Specificity of Nasal Provocation Test in Allergic Rhinitis to House Dust Mites

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Sensitivity and Specificity of Nasal Provocation Test in Allergic Rhinitis to House Dust Mites

Brief Summary: The diagnosis of allergic rhinitis to dust mites is difficult and based on three elements : suggestive symptoms of clinical sensitization to dust mites (rhinitis), the existence of an IgE sensitization defined by skin tests and / or specific IgE positive to mite and finally the presence of mite allergens in the environment where the patient is symptomatic. Unfortunately, the link between symptoms and exposure to dust mites is rarely found and according to in the literature, 30% of rhinitis sensitized to house dust mites did not react during a conventional nasal provocation test (TPNC) to dust mites. Thus, TPNC to dust mite has an interest in the diagnosis of allergic rhinitis to dust mites when there remains a doubt due to the poly sensitization of the patient, or the lack of specific symptoms and / or the variability of the allergic symptoms during the year. However, this test has not been completely validated with a study including a significant number of patients. That's why the investigators plan a prospective single-center comparative open study with the main objective is to determine the sensitivity and specificity of conventional nasal provocation test (TPNC) in 120 patients of 18 to 65 years old with allergic rhinitis sensitized to dust mites and patients with allergic rhinitis not sensitized to dust mites. The investigators secondary objective is to compare the TPNC a faster TPN-called "minute" (60 minutes) and which allow a wider use. If the investigators demonstrate the validity of TPN then it would become the gold standard needed to decide on a desensitisation to mites.

Detailed Summary:
Sponsor: University Hospital, Strasbourg, France

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Information By: University Hospital, Strasbourg, France

Dates:
Date Received: December 1, 2011
Date Started: January 2012
Date Completion:
Last Updated: March 12, 2013
Last Verified: March 2013