Clinical Trial: Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Study Recurrency Testing of Mutations Identified in WGS of Pediatric Rhabdomyosarcoma
Brief Summary:
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and find biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies genes in samples from younger patients with rhabdomyosarcoma.
Detailed Summary:
OBJECTIVES:
- To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to establish a more accurate estimate of the frequency of particular genetic lesions.
- To provide the statistical power to establish an unambiguous connection between focal genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma.
OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated from previous discovery. DNA is then eluted and sequenced by illumina platform.
Sponsor: Children's Oncology Group
Current Primary Outcome:
- Frequency of particular genetic lesions
- Identification of mutations that occur in at least 5% of rhabdomyosarcomas as a whole
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Children's Oncology Group
Dates:
Date Received: April 24, 2012
Date Started: April 2012
Date Completion:
Last Updated: May 17, 2016
Last Verified: May 2016
