Clinical Trial: Cancer Biology of Retinoblastoma

Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational

Official Title: Cancer Biology of Retinoblastoma

Brief Summary: Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.

Detailed Summary:
Sponsor: Stanford University

Current Primary Outcome: Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations [ Time Frame: After appropriate time, e.g., 7, 10, 14 days after reprogramming ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Stanford University

Dates:
Date Received: July 11, 2012
Date Started: July 2012
Date Completion:
Last Updated: March 2, 2017
Last Verified: March 2017