Clinical Trial: The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia: A Prospective Randomized Double-blinded Control Study

Brief Summary: The effects of desflurane versus sevoflurane in adult patients undergoing LMA anesthesia on respiratory events during a less than 2-hour elective surgery.

Detailed Summary:

Laryngeal Mask Airway (LMA) anesthesia is generally performed for ambulatory surgery to avoid the use of neuromuscular blocking agents and to facilitate rapid emergence from anesthesia. Inhaled anesthetics are simply and popularly used during maintenance of anesthesia. The two most recent volatile anesthetic agents, desflurane and sevoflurane, are the two most commonly used in clinical practice for an ambulatory setting.

Desflurane is the volatile agent with low blood: gas partition coefficient (0.42). Desflurane's uptake and elimination from the body of a patient are rapid, which results in a fast onset of anesthesia and a fast recovery from anesthesia. This property provides desflurane as an ideal agent for the ambulatory anesthesia. However, its pungent odor is concerned to irritate the upper airway and may cause significant respiratory complications. Sevoflurane has a blood: gas partition coefficient of 0.65, which is slightly greater than desflurane. The major advantage over desflurane is the better scent. It is considered to be less airway irritation in LMA anesthesia with smooth induction and recovery.

The limitation of desflurane on its odor leads to a controversy if desflurane is similar to or worse than sevoflurane for LMA anesthesia. This is non-inferiority study designed to compare the occurrence of respiratory complications between desflurane and sevoflurane during LMA anesthesia.


Sponsor: Chiang Mai University

Current Primary Outcome: Occurrence of respiratory complications [ Time Frame: From the beginning of operation until 30 minutes after the operation ]

Respiratory complications are coughing, breath holding, laryngospasm, bronchospasm, and desaturation


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Time of eye opening [ Time Frame: Within 30 minutes after the end of operation ]
    It is the time from discontinuation of anesthetic to the eye opening on verbal command.
  • Time to follow motor command [ Time Frame: Within 30 minutes after the end of operation ]
    It is the time from discontinuation of anesthetic to hand squeezing.
  • Time of LMA removal [ Time Frame: Within 30 minutes after the end of operation ]
    It is the time from discontinuation of anesthetic to removal of LMA.
  • Frequency of postoperative nausea and vomiting (PONV) [ Time Frame: Within 2 hours after operation ]
    It is a number of patients with PONV in the early post-anesthetic period.
  • Changes of blood pressure during anesthesia [ Time Frame: Every 15 minutes, from the beginning of operation until 30 minutes after the operation ]
    Non-invasive blood pressure will be recorded at the beginning of anesthesia, every 15 minutes during anesthetic maintenance, and at the time of LMA removal.
  • Changes of heart rate during anesthesia [ Time Frame: Every 15 minutes, from the beginning of operation until 30 minutes after the operation ]
    Heart rate will be recorded at the beginning of anesthesia, every 15 minutes during anesthetic maintenance, and at the time of LMA removal.


Original Secondary Outcome: Same as current

Information By: Chiang Mai University

Dates:
Date Received: July 24, 2016
Date Started: August 2016
Date Completion: July 2018
Last Updated: December 26, 2016
Last Verified: December 2016