Clinical Trial: Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome

Brief Summary:

Despite improving in the treatment of acute respiratory distress syndrome (ARDS), this affection keep an elevate rate of death. The strategy of mechanical ventilation is more and more under definite protocol, following large strength randomized studies. Although, it doesn't exist today element allowing to adjust the level of Positive End-Expiratory Pressure (PEEP) with improvement in patient's survival.

The investigators proposed in this study to determinate the level of PEEP adjust to obtain the better arterial oxygen transport (TaO2). The investigators going to conduct a physiologic, observational, none controlled study. All patients hospitalized in intensive care unit of Pontchaillou hospital with ARDS criteria and without specific exclusion criteria will be included. Primary objective is to looking for the optimum level of PEEP for TaO2.


Detailed Summary:
Sponsor: Rennes University Hospital

Current Primary Outcome: Determinate the Positive End-Expiratory Pressure (PEEP) level achieving the best arterial oxygen transport (TaO2) [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Evolution of pulmonary gas exchanges [ Time Frame: 1 year ]
  • Evolution of respiratory mechanism parameters [ Time Frame: 1 year ]
  • evolution of circulatory parameters and needs of catecholamine during the study [ Time Frame: 1 year ]
  • Appearance of secondary effects due to mechanical ventilation [ Time Frame: 1 year ]


Original Secondary Outcome: Same as current

Information By: Rennes University Hospital

Dates:
Date Received: December 6, 2010
Date Started: January 2011
Date Completion:
Last Updated: July 2, 2013
Last Verified: July 2013