Clinical Trial: Renal Osteodystrophy: A Fresh Approach

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Renal Osteodystrophy: A Fresh Approach

Brief Summary:

There are two major goals of this project:

  1. Comparison of DXA and QCT for diagnosis of bone loss in CKD-5 patients and determination of the prevalence of low bone turnover in CKD-5 patients with bone loss.
  2. Identification of the optimal combination of noninvasive tests for definition of the turnover component of ROD.

Detailed Summary:
Sponsor: Hartmut Malluche, MD

Current Primary Outcome: Comparison of DXA and QCT for diagnosis of bone loss in CKD-5 patients and determination of the prevalence of low bone turnover in CKD-5 patients with bone loss. [ Time Frame: 4 years ]

Because each method (QCT or DXA) yields a dichotomous response (bone loss: yes or no), the proportion of patients with a bone loss will be compared between the 2 methods by using the McNemar statistic for correlated proportions.


Original Primary Outcome:

Current Secondary Outcome: Identification of the optimal combination of noninvasive tests for definition of the turnover component of ROD. [ Time Frame: 4 years ]

A stepwise logistic model will be used to determine which combination of PTH and bone markers best predicts low bone turnover.


Original Secondary Outcome:

Information By: University of Kentucky

Dates:
Date Received: March 9, 2009
Date Started: March 2009
Date Completion:
Last Updated: May 2, 2017
Last Verified: May 2017