Clinical Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic

Brief Summary: This study is to see whether the combination regimen of ketorolac and nefopam is superior to that of ketorolac and morphine in controlling ureter stone-related acute flank pain.

Detailed Summary: The balanced analgesia regimen using both ketorolac and morphine is the most effective choice in controlling urolithiasis related acute pain. Previous animal and human studies reported that combination regimen of ketoprofen and nefopam showed synergistic effect in pain control. We hypothesized that using nefopam instead of morphine for ketorolac based combination analgesia will produce similar pain reduction without causing opioid-related side effect.
Sponsor: Seoul National University Hospital

Current Primary Outcome: Amount of pain reduction by visual analog pain scale [ Time Frame: At 30 and 60 minutes after primary study drug administration ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Additional analgesia requested by enrolled patients [ Time Frame: At 30 and 60 minutes after primary study drug administration ]

Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: February 27, 2012
Date Started: December 2012
Date Completion: December 2013
Last Updated: December 13, 2012
Last Verified: December 2012