Clinical Trial: Recurrent Respiratory Papillomatosis and Extraesophageal Reflux

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Recurrent Respiratory Papillomatosis and Extraesophageal Reflux

Brief Summary: The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).

Detailed Summary: Recurrent respiratory papillomatosis (RRP) is a chronic viral disease, which affects children and adults as well. It is characterised by grow of squamous cell tumours on mucosa of aerodigestive tract, with predilection for the larynx. The disease is caused by the human papillomavirus (HPV). However, in contrast to the low incidence of RRP, HPV prevalence is common. It is indicated that other factors may contribute to the pathogenesis of RRP. One such factor might be extraesophageal reflux (EER). We investigated whether patients with RRP suffer more often from EER.
Sponsor: University Hospital Ostrava

Current Primary Outcome: Occurrence of EER (percentage) [ Time Frame: 36 months ]

The occurrence of extra oesophageal reflux will be assessed in both study groups.


Original Primary Outcome: Same as current

Current Secondary Outcome: Presence of pepsin [ Time Frame: 36 months ]

The presence of pepsin (yes-no) will be assessed in both study groups.


Original Secondary Outcome: Same as current

Information By: University Hospital Ostrava

Dates:
Date Received: October 29, 2015
Date Started: April 2014
Date Completion: May 2018
Last Updated: May 2, 2017
Last Verified: May 2017