Clinical Trial: Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional

Official Title: Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis

Brief Summary: Juvenile onset recurrent respiratory papillomatosis (JORRP) is a rare, difficult to treat, benign tumor of the pediatric airway. Current therapy is mainly surgical, but in a significant portion of patients adjuvant therapy is required to control the disease process. Although multiple adjuvant medical therapies have been tried, success has been limited. We have seen some success in a limited amount of patients using orally administered propranolol. Our goal is to enroll a larger cohort of patients to determine the effectiveness of propranolol as an adjuvant therapy for JORRP.

Detailed Summary:
Sponsor: Massachusetts Eye and Ear Infirmary

Current Primary Outcome: Decreased number of surgeries [ Time Frame: 3 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Improved voice quality [ Time Frame: 3 months ]

Original Secondary Outcome: Same as current

Information By: Massachusetts Eye and Ear Infirmary

Dates:
Date Received: January 27, 2010
Date Started: January 2010
Date Completion:
Last Updated: November 19, 2013
Last Verified: April 2012