Clinical Trial: Oral Curcumin for Radiation Dermatitis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Oral Curcumin for Radiation Dermatitis in Breast Cancer Patients
Brief Summary: The purpose of the study is to determine whether curcumin, an ingredient of some foods, can prevent or reduce the severity of skin reactions (dermatitis) caused by radiation therapy. Dermatitis is a common side effect of radiation treatment, but few effective treatments have been developed for it. Curcumin is a natural compound found in both turmeric and curry powder. It has been used for centuries as a spice (curry), a food coloring and as a food preservative. Curcumin is non-toxic and has been found to enhance the functions of normal tissues..
Detailed Summary: Radiation is a toxic agent and a widely accepted form of treatment for various types of cancer. Approximately half of all women with breast cancer receive radiation therapy. Despite advances in medical technology, radiation therapy still causes severe skin effects. Radiation dermatitis occurs in approximately 90% of patients and ranges in severity from mild redness to more severe skin changes. Dermatitis is a common side effect of radiation treatment, but few effective treatments have been developed for it; currently, there is no standard treatment for the prevention of radiation-induced dermatitis. Curcumin is a natural compound found in both turmeric and curry powder. It has been used for centuries as a spice (curry), a food coloring and as a food preservative. Curcumin is non-toxic and has been found to enhance the functions of normal tissues.
Sponsor: University of Rochester
Current Primary Outcome: Mean Radiation Dermatitis Severity Score [ Time Frame: 6 weeks ]
Original Primary Outcome: To evaluate the degree to which curcumin can reduce radiation-induced skin reactions in breast cancer patients receiving radiotherapy. [ Time Frame: 6 weeks ]
Current Secondary Outcome: Percentage of Subjects With Moist Desquamation [ Time Frame: 6 weeks ]
Original Secondary Outcome: How curcumin can prevent or decrease the incidence of moist desquamation, redness and pain at treatment site [ Time Frame: 6 weeks ]
Information By: University of Rochester
Dates:
Date Received: November 22, 2010
Date Started: February 2011
Date Completion:
Last Updated: February 8, 2016
Last Verified: February 2016