Clinical Trial: Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: 3 T Multimodal MRI in Idiopathic RBD

Brief Summary: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is characterized by nocturnal violence, increased muscle tone during REM sleep and the lack of any other neurological disease. However, iRBD can precede parkinsonism and dementia by several years. The causes of the loss of muscle atonia during REM sleep in these patients are unclear. Using 3 T MRI and neuromelanin- sensitive sequences, the signal intensity was previously found to be reduce in the locus coeruleus/subcoeruleus area of patients with Parkinson's disease and RBD. Here, the investigators aimed at studying the integrity of the locus coeruleus/ subcoeruleus complex with neuromelanin-sensitive imaging in 21 patients with iRBD and compared the results with those from 21 age- and gender-matched healthy volunteers. All subjects will undergo a clinical examination, motor, cognitive, autonomous, psychological, olfactory and color vision tests, and rapid eye movement sleep characterization using video-polysomnography and 3 T magnetic resonance imaging.

Detailed Summary:
Sponsor: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le So

Current Primary Outcome: Signal in the subcoeruleus/coeruleus complex [ Time Frame: 24h ]

Brain imaging signal in the subcoeruleus/coeruleus complex in 3T multimodal MRI, using neuromelanin-sensitive sequence


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Substantia nigra quantity [ Time Frame: 24h ]
    size of the substantia nigra
  • Quality of Sleep [ Time Frame: 24h ]
    Measures in videopolysomnography of efficiency of sleep
  • Cognition [ Time Frame: 24h ]
    Cognition status (MoCA test)
  • Olfactory function [ Time Frame: 24h ]
    Olfactory function (sniff test)
  • Color vision [ Time Frame: 24h ]
    Color vision function


Original Secondary Outcome: Same as current

Information By: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le So

Dates:
Date Received: February 28, 2017
Date Started: February 2014
Date Completion:
Last Updated: March 7, 2017
Last Verified: March 2017