Clinical Trial: Gait and REM Sleep Behavior Disorder

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Recherche et Mesure d'Anomalies précoces de la Marche au Cours Des Troubles du Comportement en Sommeil Paradoxal Idiopathiques

Brief Summary:

Many people with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which are Parkinson's disease (PD) and Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common in the synucleinopathies, early abnormalities in gait in those with RBD could help in identifying those at increased risk of developing overt parkinsonism and/or cognitive impairment.

The investigators aim to identify subtle gait abnormalities in idiopathic RBD and to identify sensitive and early biomarkers:

  1. to detect subtle gait disorders in pre-symptomatic stage of synucleinopathy and
  2. to track their evolution in the parallel with the disease progression.

Main objective: In comparison with age and gender matched-controls, to identify in patients with RBD a larger reduction of gait velocity (and other abnormalities of spatio-temporal characteristics of gait) between a single (gait) and a dual-task (gait+cognitive task).

Secondary objective:

  1. In comparison with age and gender matched-PD patients, to identify in patients with RBD a smaller reduction of gait velocity (and other abnormalities of spatio-temporal characteristics of gait) between a single (gait) and a dual-task (gait+cognitive task).
  2. In patients with RBD to identify correlations between the spatio-temporal characteristics modifications of gait between a single (gait) and a dual-task (gait+cognitive task) and the percenta

    Detailed Summary:
    Sponsor: University Hospital, Montpellier

    Current Primary Outcome: gait velocity [ Time Frame: Month 24 ]

    gait speed difference between single and dual tasks


    Original Primary Outcome: Same as current

    Current Secondary Outcome: spatio-temporal gait characteristics [ Time Frame: Month 24 ]

    oscillation phase duration difference between single and dual tasks


    Original Secondary Outcome: Same as current

    Information By: University Hospital, Montpellier

    Dates:
    Date Received: May 6, 2015
    Date Started: April 2014
    Date Completion: April 2017
    Last Updated: September 17, 2015
    Last Verified: September 2015