Clinical Trial: Antibiotic Prophylaxis in Children With Pyelonephritis
Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional
Official Title: A Randomized Controlled Trial of Antibiotic Prophylaxis in Children With Pyelonephritis in the Abscence of Vesicoureteral Reflux
Brief Summary: Children who present with pyelonephritis undergo many investigations, and long term care to prevent renal damage. The focus is primarily on preventing renal failure however along the way and particularly with children, other issues arise which impact their lives, as well as their family's lives. Parents are concerned about subjecting their children to invasive procedures and long term antibiotic use, particularly if they are not sure of the benefit. This study seeks to provide information on the impact of investigation and long term antibiotic treatment in reference to long term health and quality of life in children who present with febrile urinary tract infections in the absence of anatomic abnormalities.
Detailed Summary:
Sponsor: University of Alberta
Current Primary Outcome: To determine whether antibiotic prophylaxis prevents recurrent urinary tract infections by assessing if there is a decreased incidence of urinary tract infections. [ Time Frame: one year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- To determine whether antibiotic prophylaxis prevents long-term renal scarring by assessing results of DMSA scans to look at long term renal scarring. [ Time Frame: One year and five years ]
- To determine whether recurrent infections and involvement with the medical system impacts quality of life by assessing how this medical condition affects children using standardized quality of life questionnaires. [ Time Frame: Yearly for five years ]
Original Secondary Outcome: Same as current
Information By: University of Alberta
Dates:
Date Received: September 11, 2008
Date Started: February 2009
Date Completion:
Last Updated: January 14, 2015
Last Verified: January 2015
