Clinical Trial: Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure

Brief Summary: The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.

Detailed Summary: Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.
Sponsor: Johannes Gutenberg University Mainz

Current Primary Outcome: Change from Baseline cerebrovascular autoregulation due to elevated positive end-expiratory pressure [ Time Frame: 1 Year ]

Is there an impairment of cerebrovascular autoregulation due to positive end-expiratory pressure ventilation this will be a major side effect especial in patients with brain injury.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Johannes Gutenberg University Mainz

Dates:
Date Received: June 14, 2011
Date Started: January 2011
Date Completion:
Last Updated: June 17, 2011
Last Verified: August 2010