Clinical Trial: Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Observational Study of Comparison of Echocardiographic Markers of Right Ventricular Function and Electrocardiographic Signs of Chronic Cor Pulmonale in Elderly Patient Wit

Brief Summary: Many studies have evaluated the viability of measuring the pulmonary vascular resistance (PVR) by non-invasive methods in patients with pulmonary hypertension, pulmonary thromboembolism, ischemic cardiopathy and valvular disease. The investigators have not found other studies which evaluate the PVR in elderly patients with COPD. The hypothesis is that in patients with COPD, the severity of obstruction, expressed by GOLD class, is associated with an increase of PVR.

Detailed Summary:
Sponsor: Hospital Viamed Valvanera, Spain

Current Primary Outcome: right ventricular function and GOLD stages [ Time Frame: cross sectional ]

To compare right ventricular function, evaluated by a non-invasive method such as echocardiography, with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients.


Original Primary Outcome: PVR and FEV1.

Compare pulmonary vascular resistance (PVR), evaluated by a non-invasive method such as echocardiography, with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients.


Current Secondary Outcome:

  • Right ventricular function and FEV1. [ Time Frame: cross sectional ]
    Compare right ventricular function, evaluated by a non-invasive method such as echocardiography, tricuspid annulus plane systolic excursion (TAPSE),pulmonary artery systolic pressure (PAPs) and fractional area change (FAC), with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients.
  • ECG and echocardiography parameters of cor pulmonale [ Time Frame: cross sectional ]
    The correlation between right ventricular function and the electrocardiographic parameters of cor pulmonale.
  • Right ventricle function and 6M-WT. [ Time Frame: cross sectional ]
    Evaluate the correlation between the hemodynamic indices of right ventricle and the six minute walking test (6M-WT).


Original Secondary Outcome:

  • Right ventricular function and FEV1.
    Compare right ventricular function, evaluated by a non-invasive method such as echocardiography, tricuspid annulus plane systolic excursion (TAPSE),pulmonary artery systolic pressure (PAPs) and fractional area change (FAC), with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients.
  • ECG and echocardiography parameters of cor pulmonale
    The correlation between right ventricular function and the electrocardiographic parameters of cor pulmonale.
  • Right ventricle function and 6M-WT.
    Evaluate the correlation between the hemodynamic indices of right ventricle and the six minute walking test (6M-WT).


Information By: Hospital Viamed Valvanera, Spain

Dates:
Date Received: March 2, 2012
Date Started: March 2012
Date Completion:
Last Updated: February 6, 2015
Last Verified: February 2015