Clinical Trial: Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Sleep Apnea and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders

Brief Summary: High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary circulation. Whether sleep related breathing disturbances, common causes of nocturnal hypoxemia in lowlanders, are also prevalent in highlanders and promote pulmonary hypertension in highlanders is unknown. Therefore, the current study will investigate whether highlanders with high altitude pulmonary hypertension have a greater prevalence of sleep apnea than healthy highlanders and lowlanders.

Detailed Summary:
Sponsor: University of Zurich

Current Primary Outcome: Sleep related breathing disturbances [ Time Frame: 4 months ]

Nocturnal oxygen saturation and apnea/hypopnea index


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Pulmonary artery pressure [ Time Frame: 4 months ]
    Echocardiography
  • Dyspnea [ Time Frame: 4 months ]
    NYHA functional class
  • Vigilance [ Time Frame: 4 months ]
    Psychomotor vigilance
  • Exercise performance [ Time Frame: 4 months ]
    6 min walk test
  • Pulmonary function [ Time Frame: 4 months ]
    Spirometry
  • Cerebral oxygen saturation [ Time Frame: 4 months ]
    Near-infrared spectroscopy
  • Mountain sickness [ Time Frame: 4 months ]
    Quinghai chronic mountain sickness score
  • Generic quality of life [ Time Frame: 4 months ]
    SF-36 quality of life questionnaire
  • Disease specific quality of life [ Time Frame: 4 months ]
    Kansas City Cardiomyopathy questionnaire
  • Subjective sleepiness [ Time Frame: 4 months ]
    Epworth sleepiness scale


Original Secondary Outcome:

  • Pulmonary artery pressure [ Time Frame: 4 months ]
    Echocardiography
  • Symptoms [ Time Frame: 4 months ]
    NYHA functional class, Quinghai chronic mountain sickness score, SF-36 quality of life questionnaire, Kansas City Cardiomyopathy questionnaire, Epworth sleepiness scale
  • Vigilance [ Time Frame: 4 months ]
    Psychomotor vigilance
  • Exercise performance [ Time Frame: 4 months ]
    6 min walk test
  • Pulmonary function [ Time Frame: 4 months ]
    Spirometry
  • Cerebral oxygen saturation [ Time Frame: 4 months ]
    Near-infrared spectroscopy


Information By: University of Zurich

Dates:
Date Received: June 13, 2012
Date Started: June 2012
Date Completion:
Last Updated: May 14, 2014
Last Verified: May 2014