Clinical Trial: Prevention of High Altitude Pulmonary Edema
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: A Randomized Controlled Trial of the Effects of Tadalafil and Dexamethasone Versus Placebo on Pulmonary Edema Formation and Cerebral Blood Flow Autoregulation in High Altitude Newcomers With a Previou
Brief Summary:
A double-blind placebo controlled study
- To compare the effect of tadalafil and dexamethasone versus placebo on Ppa and pulmonary edema formation in subjects susceptible to HAPE.
- To investigate the effect of dexamethasone on alveolar fluid clearance, as assessed by measurement of the nasal potential difference, and prevention of HAPE.
- To investigate the effect of the tadalafil and dexamethasone versus placebo on the dynamic CBF autoregulation properties and on the development of AMS in HAPE susceptible subjects.
Detailed Summary:
Sponsor: University of Zurich
Current Primary Outcome: prevention of high altitude pulmonary edema
Original Primary Outcome: Same as current
Current Secondary Outcome: incidence of acute mountain sickness
Original Secondary Outcome: Same as current
Information By: University of Zurich
Dates:
Date Received: January 9, 2006
Date Started: July 2003
Date Completion: September 2003
Last Updated: November 30, 2006
Last Verified: December 2003
