Clinical Trial: CPAP Versus NPPV in ACPE
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre T
Brief Summary: To assess the intubation rate in patients affected by severe cardiogenic pulmonary edema treated with CPAP or NPPV.
Detailed Summary:
Background Although non-invasive ventilation has shown to be an effective treatment for acute cardiogenic pulmonary oedema (ACPO), literature still lacks of multi-centre randomised prospective studies that compares CPAP with NPPV.
Aim of the study was to assess efficacy and safety of CPAP and NPPV in patients with ACPO.
Methods 80 patients with ACPO were randomly assigned to receive CPAP or NPPV (40 for each group) through a face mask.
Inclusion criteria were: severe dyspnoea, respiratory rate > 30, PaO2/FiO2 < 200, muscle fatigue.
Main end-points were endotracheal intubation, length of ventilation, hospital length of stay and mortality.
Sponsor: Ospedale S. Giovanni Bosco
Current Primary Outcome: Intubation rate
Original Primary Outcome: Same as current
Current Secondary Outcome:
- time of recovery
- hospital length of stay
- mortality and improvement in gas exchange
Original Secondary Outcome: Same as current
Information By: Ospedale S. Giovanni Bosco
Dates:
Date Received: March 12, 2007
Date Started: July 2002
Date Completion:
Last Updated: April 2, 2007
Last Verified: April 2007
