Clinical Trial: Echocardiographic Evaluation of Hypertensive Acute Pulmonary Edema

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Echocardiographic Evaluation of Hypertensive Acute Pulmonary Edema

Brief Summary:

Acute cardiogenic pulmonary edema (ACPE), one of the most severe forms of acute heart failure, represents 5% of hospital admissions. One of the most frequent phenomena encountered during ACPE is hypertensive crisis (hypertensive ACPE) but the mechanisms and causes of hypertensive ACPE are insufficiently understood. Few studies have evaluated the cardiac function during hypertensive ACPE, and these studies used only conventional echocardiography methods. New methods of evaluation of cardiac function in hypertensive ACPE (such as Tissue Doppler imaging) have not been used.

The objectives of this study are to evaluate presence and role of the following potential mechanisms of hypertensive ACPE: 1. acute myocardial dysfunction (systolic and diastolic); 2. silent transient myocardial ischemia; 3. acute mechanical left ventricular dyssynchrony; 4. dynamic mitral regurgitation; 5. inter-ventricular interaction. Conventional and Tissue Doppler echocardiography will be used to assess cardiac function.


Detailed Summary:
Sponsor: Carol Davila University of Medicine and Pharmacy

Current Primary Outcome: acute myocardial dysfunction (systolic and diastolic) and/or dyssynchrony [ Time Frame: acute event and 48 to 96 h after the event ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • surrogate markers of silent transient myocardial ischemia [ Time Frame: acute event and 48 to 96 h after the event ]
  • dynamic mitral regurgitation [ Time Frame: acute event and 48 to 96 h after the event ]
  • inter-ventricular interaction [ Time Frame: acute event and 48 to 96h after the event ]


Original Secondary Outcome: Same as current

Information By: Carol Davila University of Medicine and Pharmacy

Dates:
Date Received: January 26, 2009
Date Started: May 2008
Date Completion:
Last Updated: March 4, 2013
Last Verified: March 2013