Clinical Trial: Peroperative Use of Positive End-expiratory Pressure Prevents Formation of Atelectasis as Studied by Computerised Tomography at End of Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Peroperative Use of Positive End-expiratory Pressure Prevents Formation of Atelectasis as Studied by Computerised Tomography at End of Surgery

Brief Summary:

Atelectasis is common during and after general anaesthesia and a number of interventions have been suggested in order to prevent their formation. The use of Positive End Expiratory Pressure (PEEP) during general anaesthesia has in recent years been questioned.

The investigators hypothesize that the use of PEEP as a single intervention improves oxygenation and prevents atelectasis as investigated by computed tomography compared to a control group with zero PEEP.


Detailed Summary:
Sponsor: Landstinget Västmanland

Current Primary Outcome:

  • Area of atelectasis expressed as centimeter^2 [ Time Frame: Within 1-2 hours, just before emergence from anesthesia.The outcome measure (atelectasis) will be investigated at just one point i.e. end of surgery but before emergence from anaesthesia. ]
    The area of atelectasis in the lungs is assessed by computed tomography (CT) 5-10 mm above the dome of the right diaphragm and expressed in centimeter^2 and as a percentage of the total lung area in the particular scan.
  • Measurement of aeras with different aeration in the particular CT scan. [ Time Frame: Within 1-2 hours, just before emergence from anesthesia.The outcome measure (atelectasis) will be investigated at just one point i.e. end of surgery but before emergence from anaesthesia. ]
    The areas of different aeration are assessed by computed tomography (CT) 5-10 mm above the dome of the right diaphragm and expressed in centimeter^2 and as a percentage of the total lung area in the particular scan.


Original Primary Outcome: Area of atelectasis expressed as centimeter^2 [ Time Frame: Within 1-2 hours, just before emergence from anesthesia.The outcome measure (atelectasis) will be investigated at just one point i.e. end of surgery but before emergence from anaesthesia. ]

The area of atelectasis in the lungs is assessed by computed tomography (CT) 5-10 mm above the dome of the right diaphragm and expressed in centimeter^2 and as a percentage of the total lung area in the particular scan.


Current Secondary Outcome:

  • Oxygenation, oxygen tension in arterial blood expressed in kilo Pascal (kPa) [ Time Frame: Within 1-2 hours, just before emergence from anesthesia. At end of surgery but before emergence from anaesthesia, at the same time as the lungs are investigated by computed tomography. ]
    Arterial blood gas samples will be drawn and analyzed at the same time as the computed tomography scan will be undertaken.
  • Oxygenation, oxygen tension in arterial blood expressed in kilo Pascal (kPa) [ Time Frame: Within 2 hours perioperatively, 15 minutes after extubation. ]
    Arterial blood gas samples will be drawn and analyzed 15 minutes after emergence from anesthesia and extubation.


Original Secondary Outcome: Same as current

Information By: Landstinget Västmanland

Dates:
Date Received: September 1, 2015
Date Started: November 2015
Date Completion:
Last Updated: November 20, 2016
Last Verified: November 2016