Clinical Trial: Atelectasis After Pulmonary Lobectomy: The Effect Of Air During One-Lung Ventilation (OLV) On Postoperative Atelectasis

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Atelectasis After Pulmonary Lobectomy: The Effect Of Air During One-Lung Ventilation (OLV) On Postoperative Atelectasis.

Brief Summary:

Patients scheduled for lung lobe resection using video assisted thoracic surgery will be randomly assigned to be ventilated with either only oxygen or a mixture of air and oxygen.

The primary purpose of this study is to determine if the incidence of postoperative collapse (in the non-surgical lung) is decreased when using a mixture of air and oxygen compared to using only oxygen (which is our control measurement) during one-lung ventilation.


Detailed Summary:

One of the concerns with all thoracic procedures employing One Lung Ventilation (OLV) is intra-operative hypoxia due to the large shunt that develops when only one lung is being ventilated. Ventilation with a higher fraction of inspired oxygen (FIO2) is one of the commonly chosen strategies for the treatment of hypoxemia during (OLV) for thoracic surgery. Using an FIO2 of 1.0 at all times during (OLV), however, may increase the risk of absorption atelectasis intra and postoperatively which itself leads to persistent hypoxia and potentially pneumonia.

The aim of this study is therefore to determine the impact of adding air to the inspired fraction of oxygen during (OLV) primarily on the incidence of postoperative atelectasis of the nonsurgical lung after lung resection using video assisted thoracic surgery and secondarily on intraoperative and postoperative oxygenation.


Sponsor: London Health Sciences Centre

Current Primary Outcome: The incidence of postoperative atelectasis [ Time Frame: Immediately after the surgery - up to 2 days post operative. ]

The primary objective is to determine if the incidence of postoperative atelectasis is decreased in the non-surgical lung, during one-lung ventilation (OLV) with mixture of air and oxygen compared to (OLV) using only oxygen (which is our control measurement) .


Original Primary Outcome: Same as current

Current Secondary Outcome: The incidence of intraoperative and postoperative hypoxia (SpO2 < 90%) . [ Time Frame: Intra-operative and Post operative day 1 and 2 . ]

Original Secondary Outcome: Same as current

Information By: London Health Sciences Centre

Dates:
Date Received: February 1, 2011
Date Started: July 2010
Date Completion: June 2011
Last Updated: February 2, 2011
Last Verified: February 2011