Clinical Trial: Imaging Outcomes of Cognitive Behavioral Therapy (CBT) for Battered Women With Posttraumatic Stress Disorder
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Neurobiology of Severe Psychological Trauma in Women
Brief Summary: Identifying neural mechanisms of posttraumatic stress disorder (PTSD) treatment could help elucidate reasons for variable treatment response and identify novel treatment targets. Exposure-based therapies have been associated with decreased amygdala and increased cingulate cortex response during emotional processing. The current study examined whether cognitive therapy for PTSD in women reduces activation in insula and amygdala and enhances activation in prefrontal regions during emotional anticipation and pre-treatment prefrontal activation predicts treatment response.
Detailed Summary:
Sponsor: University of California, San Diego
Current Primary Outcome: Clinician-Administered PTSD Scale (CAPS) [ Time Frame: After 10 sessions of cognitive behavioral therapy (CBT) (10-14 weeks) ]
Original Primary Outcome: Same as current
Current Secondary Outcome: CAPS 3 months post-treatment [ Time Frame: 3 months post-treatment ]
Original Secondary Outcome: Same as current
Information By: University of California, San Diego
Dates:
Date Received: January 16, 2012
Date Started: January 2008
Date Completion:
Last Updated: January 21, 2012
Last Verified: January 2012