Clinical Trial: Arterial Wall Calcium Load in Pseudoxanthoma Elasticum
Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational
Official Title: Arterial Wall Calcium Load and Preferential Sites in Pseudoxanthoma Elasticum Versus Type 2 Diabetes and Chronic Kidney Disease.
Brief Summary: Quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between Pseudo-Xanthoma elasticum(PXE) atients and type 2 diabetics and Chronic Kidney disease.
Detailed Summary:
In a previous work we have observed that patients suffering from PXE, a soft-tissue calcifying inherited autosomal disease, exhibited specific structural and functionnal features within the peripheral arteries. We now want to quantify and determine the preferential sites of the arterial wall calcification (Agatston score) between these patients compared to diabetics and patients with chronic renal insufficiency with mediacalcosis.
All variables will be collected from a cohort of PXE monitored in our PXE Health and Care centre at the university hospital of Angers. Quantification of the arterial wall calcium load will be performed using helicoidal CT-scan. These variables will be compared to the same measurements performed in type 2 diabetic and chronic kidney disease patients paired by age and gender.
Sponsor: University Hospital, Angers
Current Primary Outcome: calcification score [ Time Frame: after inclusion ]
Original Primary Outcome: Same as current
Current Secondary Outcome: site of calcification [ Time Frame: after inclusion ]
Original Secondary Outcome: Same as current
Information By: University Hospital, Angers
Dates:
Date Received: November 14, 2012
Date Started: January 2012
Date Completion: July 2013
Last Updated: November 20, 2012
Last Verified: November 2012