Clinical Trial: Arterial Wall Calcium Load in Pseudoxanthoma Elasticum

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Arterial Wall Calcium Load and Preferential Sites in Pseudoxanthoma Elasticum Versus Type 2 Diabetes and Chronic Kidney Disease.

Brief Summary: Quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between Pseudo-Xanthoma elasticum(PXE) atients and type 2 diabetics and Chronic Kidney disease.

Detailed Summary:

In a previous work we have observed that patients suffering from PXE, a soft-tissue calcifying inherited autosomal disease, exhibited specific structural and functionnal features within the peripheral arteries. We now want to quantify and determine the preferential sites of the arterial wall calcification (Agatston score) between these patients compared to diabetics and patients with chronic renal insufficiency with mediacalcosis.

All variables will be collected from a cohort of PXE monitored in our PXE Health and Care centre at the university hospital of Angers. Quantification of the arterial wall calcium load will be performed using helicoidal CT-scan. These variables will be compared to the same measurements performed in type 2 diabetic and chronic kidney disease patients paired by age and gender.


Sponsor: University Hospital, Angers

Current Primary Outcome: calcification score [ Time Frame: after inclusion ]

the level of arterial wall calcification determined by a Ct-scan and computed by the Agatston score


Original Primary Outcome: Same as current

Current Secondary Outcome: site of calcification [ Time Frame: after inclusion ]

the anatomical site of arterial wall calcification determined by a Ct-scan and computed by the Agatston score


Original Secondary Outcome: Same as current

Information By: University Hospital, Angers

Dates:
Date Received: November 14, 2012
Date Started: January 2012
Date Completion: July 2013
Last Updated: November 20, 2012
Last Verified: November 2012