Clinical Trial: Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia

Brief Summary: The purpose of this research study is to see if a specific protein that we are interested in is involved in scarring hair loss. If these proteins are involved, further genetic work may also better define the disease as well as future treatment options.

Detailed Summary: This is a single-center study, designed to evaluate the expression of Fas protein in skin biopsies of patients with scarring alopecia including fourteen patients with central centrifugal scarring alopecia (CCSA), three patients with lichen planopilaris (LP) and three patients with discoid lupus erythematosus (DLE). Skin biopsies of five healthy participants will be used as controls.
Sponsor: Wake Forest University

Current Primary Outcome: To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosus (DLE) and in healthy controls. [ Time Frame: 8 weeks ]

Original Primary Outcome: To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosous (DLE) and in healthy controls. [ Time Frame: 8 weeks ]

Current Secondary Outcome: To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia before and after treatment with intralesional and topical steroids. [ Time Frame: 8 weeks ]

Original Secondary Outcome: Same as current

Information By: Wake Forest University Health Sciences

Dates:
Date Received: June 2, 2008
Date Started: April 26, 2006
Date Completion:
Last Updated: January 24, 2017
Last Verified: January 2017