Clinical Trial: Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: Prospective Observational Study of Peritoneal Surface Malignancies (PSM) - Characterization, Models and Treatment Strategies.

Brief Summary: The aim of this study is to identify biomarkers of disease recurrence and prognosis to optimize patient selection for treatment with cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), and through animal models to explore different treatment strategies for peritoneal surface malignancies (PSM).

Detailed Summary: The handling of patients with PSM involves multimodal and multidisciplinary treatment strategies such as CRS, the removal of all macroscopically detectable tumor, and HIPEC, instillation of heated chemotherapy in the abdominal cavity to remove residual cancer disease. The treatment is challenging and complex and associated with significant morbidity. Only patients with limited disease will benefit from the treatment, and better methods for patient selection are needed. The project group has a unique opportunity to address key questions because of acquired experience, an exceptional biobank and institutional database and novel animal models established at the Norwegian Radium Hospital.
Sponsor: Oslo University Hospital

Current Primary Outcome: Overall survival (OS) [ Time Frame: 5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Progression-free survival (PFS) [ Time Frame: 5 years ]

Original Secondary Outcome: Same as current

Information By: Oslo University Hospital

Dates:
Date Received: February 17, 2014
Date Started: September 2009
Date Completion: January 2023
Last Updated: October 14, 2015
Last Verified: October 2015