Clinical Trial: Topical Aprepitant in Prurigo Patients
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Topical Aprepitant in Prurigo Patients An Exploratory Phase IIa Trial With Topically Applied Aprepitant in Patients With Prurigo
Brief Summary: Topical Aprepitant in Prurigo Patients - An Exploratory Phase IIa Trial With Topically Applied Aprepitant in Patients With Prurigo
Detailed Summary:
Sponsor: LEO Pharma
Current Primary Outcome: efficacy of topical aprepitant treatment [ Time Frame: 4 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- efficacy of topical applied aprepitant [ Time Frame: 4 weeks ]To assess efficacy of topical applied aprepitant on the status of the skin condition compared to placebo, after 4 weeks of treatment using patient global assessment and clinical score
- long-term effect of topical applied aprepitant [ Time Frame: 6 weeks ]To assess long-term effect (e.g., duration of action, duration of reduction of pruritus) of topical applied aprepitant in comparison to placebo, after a follow up period of 2 weeks at the end of the treatment
- effect of topical applied aprepitant on skin structures [ Time Frame: 4 weeks ]To assess effect of topical applied aprepitant on skin structures in comparison to placebo, after 4 weeks of treatment using TEWL (Transepidermal Water Loss)
Original Secondary Outcome: Same as current
Information By: LEO Pharma
Dates:
Date Received: September 18, 2013
Date Started: October 2013
Date Completion:
Last Updated: October 6, 2014
Last Verified: February 2014