Clinical Trial: Efficacy and Safety of Losartan in Pediatric Chronic Kidney Disease With Tubular Proteinuria

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: A Prospective, Randomized, Cross-over Study Evaluating the Efficacy and Safety of Losartan in Pediatric Chronic Kidney Disease With Tubular Proteinuria

Brief Summary: The investigators hypothesize that using Losartan would help decrease proteinuria in pediatric chronic kidney disease with tubular proteinuria.

Detailed Summary:
Sponsor: Seoul National University Hospital

Current Primary Outcome: the change in urinary protein-creatinine ratio from baseline to the end of 12 weeks [ Time Frame: 12 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • the change in urinary albumin-creatinine ratio from baseline to the end of study [ Time Frame: 12 weeks ]
  • the proportion of patients wifh more than 50% decrease of urinary protein-creatinine ratio [ Time Frame: 12 weeks ]
  • the change in urinary beta2-microglobulin-creatinine ratio from baseline to the end of study [ Time Frame: 12 weeks ]
  • the change in urinary NAG-creatinine ratio from baseline to the end of study [ Time Frame: 12 weeks ]


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: September 3, 2014
Date Started: September 2014
Date Completion: November 2016
Last Updated: September 3, 2014
Last Verified: September 2014